Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination.

نویسنده

  • M D Schechter
چکیده

Experiments were conducted to investigate the functional consequences of a neurotoxic regimen of MDMA administration upon two behaviors, conditioned place preference and drug discrimination. Rats were trained to discriminate 1.5 mg/kg MDMA from its vehicle and their discriminative performance was shown to be dose-responsive. Subsequently, MDMA was observed to produce a conditioned place preference as three conditioning sessions with 1.5 mg/kg MDMA paired with the nonpreferred chamber increased the time the rats spent in the chamber paired with MDMA. Administration of a proportedly neurotoxic dose (20 mg/kg subcutaneous) of MDMA, twice-a-day for four days, did not affect this conditioned place preference when it was redetermined at a time of maximal neurochemical compromise. In contrast, sensitivity to 1.0 mg/kg MDMA in the drug discrimination task was shown to be significantly decreased after the neurotoxic regimen. Results are discussed in light of MDMA effects upon both central serotonergic and dopaminergic neurons.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of MDMA (ecstasy) on activity and cocaine conditioned place preference in adult and adolescent rats.

MDMA (ecstasy) is a drug commonly used in adolescence, and many users of MDMA also use other illicit drugs. It is not known whether MDMA during adolescence alters subsequent responses to cocaine differently than in adults. This study examined the effects of MDMA in adolescent and adult rats on cocaine conditioned reward. At the start of these experiments, adolescent rats were at postnatal day (...

متن کامل

Comparing of the Effects of Hypericin and Synthetic Antidepressants on the Expression of Morphine-Induced Conditioned Place Preference

The effect of hypericin on the expression of morphine-induced conditioned place preference (CPP) was investigated and compared with the effect of the synthetic antidepressants. The CPP paradigms took place over six days using an unbiased procedure. The results demonstrate that intra-peritoneal (IP) injection of morphine sulfate (2.5, 5 and 10 mg/Kg) significantly induce the CPP in rat. Intra-pe...

متن کامل

Sensitivity change of dopamine receptors in hippocampus (CA1) and its effect on morphine-induced condition place preference

In the present study, the effects of intra-cerebral hippocampus (CA1) injections of apomorphine D1, D2-like receptors agonists on morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different dose of morphine sulphate (1, 3, 6 and 9 mg/kg) produced a dose-dependent conditioned place preference (CPP). Intra-cerebral hippocampus (CA1) admin...

متن کامل

A study on the role of nitric oxide in morphine dependence using conditioned place preference

Drug abuse and dependence have progressively become a dramatic problem in human societies. Since the exact mechanism(s) of the effect of related drugs in the brain has not been explored, therefore, this problem has not been resolved yet. Several lines of evidence indicated that nitric oxide (NO) plays an important role in the process of drug dependence. The role of NO within the different regio...

متن کامل

Effect of linalool on the acquisition and reinstatement of morphine-induced conditioned place preference in mice

Objective: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice.Material and Methods: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 4...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Pharmacology, biochemistry, and behavior

دوره 38 3  شماره 

صفحات  -

تاریخ انتشار 1991